• SynVivo is a physiological, cell-based microchip platform that provides a morphologically and biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery.

  • We have prepared a short video explaining how SynVivo works. Take a look and see what it is all about!

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  • The SynVivo microfluidic cell-based assay platform has been recognized as one of the "Top 10 Innovations of 2013" by The Scientist magazine.

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  • SynVivo can be used for basic research, drug discovery, improving drug delivery, and ADME/Tox.
  • A wide range of SynVivo chips are available, in both idealized and simulated in vivo constructs.
  • SynVivo’s patented technology recreates microvascular scale, shape, fluidics, and cellular constructs.

Screening for Drug Particles

Different shapes of particles were obtained and coated with anti-BSA antibody. SynVivo walls were coated with BSA. Particles were injected into SynVivo and the adhesion quantified.

SEM Images of Particle Shapes

Comparison between Linear Channels and Microvascular Networks

Outcome:

Linear channel assays cannot differentiate between various shapes, whereas Microvascular Networks can. As particle shape becomes a more relevant area of study for drug delivery, SynVivo can provide new insights that can help optimize drug delivery.