• SynVivo is a physiological, cell-based microchip platform that provides a morphologically and biologically realistic microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery.

  • We have prepared a short video explaining how SynVivo works. Take a look and see what it is all about!

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    Applications

    SynVivo can be used for basic research, drug discovery, improving drug delivery, and ADME/Tox.
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    Products

    A wide range of SynVivo chips are available, in both idealized and simulated in vivo constructs.
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    Technology

    SynVivo’s patented technology recreates microvascular scale, shape, fluidics, and cellular constructs.

Targeted Drug Delivery

A confluent layer of endothelial cells were activated with cytokines. Anti-ICAM-1 coated particles were used for targeting (red dots) and IgG particles served as controls (green dots). Data was obtained at 4 and 24 hours post treatment.

Time Lapse Image of Confluent Layer of Endothelial Cells

Particle Interaction on Inflammed Endothelium

Particle Bound on Inflamed Endothelium

Outcome:

SynVivo can support the growth of endothelial cells (and many other cell types) to further improve the resolution and broaden the application of the assay kit. In addition, targeted drug delivery can be quantified using inflammation assays.