Basic Research

Cellular behavior and microcirculatory dysfunction:

SynVivo chips can be used to study real-time cell-cell interactions for:
  • Inflammation (leukocyte-endothelium),
  • Cancer (tumor-endothelium),
  • Thrombosis (platelet-endothelium), and
  • Infection (microbial-endothelium)
under physiological fluid flow conditions representing healthy and pathological conditions.
Leukocytes rolling and adhering on endothelial cells
Infection of brain neuronal cells
Infection on neuronal cells

Drug particle adhesion and uptake mechanisms:

Drug particle adhesion is the critical step for successfully delivery of drugs. Use SynVivo to decipher the adhesion mechanisms of particles and subsequent uptake by cells under healthy and pathological conditions.
Antibody coated drug particles interacting with endothelial cells and protein coated channels

Drug Delivery

SynVivo chips predict targeting efficacies of drugs in vivo by mimicking the cellular makeup of desired cell populations. Use SynVivo to optimize drug delivery to target cells.

Gene Delivery Polymers and GFP expressing Tumor Cells

Drug Discovery

SynVivo chips allow screening of drugs (chemical and biological) under conditions mimicking in vivo scenario. Reduce false positive and false negative outcomes resulting in rapid screening of drugs.

Scalable for high throughput/content

ADME/Tox

SynVivo chips allow drug interactions under both perfusion and diffusion based conditions. Use SynVivo to characterize drug toxicity and selection of optimal drug for desired pathological condition.

Drug Toxicity Analysis

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