Cellular behavior and microcirculatory dysfunction:
SynVivo chips can be used to study real-time cell-cell interactions for:
under physiological fluid flow conditions representing healthy and pathological conditions.
- Inflammation (leukocyte-endothelium),
- Cancer (tumor-endothelium),
- Thrombosis (platelet-endothelium), and
- Infection (microbial-endothelium)
Leukocytes rolling and adhering on endothelial cells
Infection of brain neuronal cells
Infection on neuronal cells
Drug particle adhesion and uptake mechanisms:
Drug particle adhesion is the critical step for successfully delivery of drugs. Use SynVivo to decipher the adhesion mechanisms of particles and subsequent uptake by cells under healthy and pathological conditions.
Antibody coated drug particles interacting with endothelial cells and protein coated channels