Technology

SynVivo’s patented technology for recreating microvasculature scale, shape, fluidics, and cellular constructs provides the most realistic in vitro testing platform for drug discovery, delivery, efficacy, and toxicity assays.

Static well plate and linear flow channel assays cannot differentiate between shapes of drug delivery vehicles, whereas SynVivo can. As particle shape becomes a more relevant area of study for drug delivery, SynVivo can provide new insights that can help optimize drug delivery.

What it Does

SynVivo can be used to capture real-time distribution of drugs in the microvasculature. Stagnant and recirculation zones that affect overall drug delivery and distribution can be readily identified.

SynVivo can be used to quantify drug particle distribution patterns through analysis of shear rate and adhesion.

SynVivo can support the growth of endothelial cells, cancer cells and many other cell types for mimicking healthy and disease conditions. In addition, targeted drug delivery can be quantified and optimized using the in vivo morphology and fluidic conditions in SynVivo.

How it Works

Watch this short video to get an idea of how SynVivo works...

How it's Made

Starting with the scans of animal or human microvasculature networks, SynVivo creates a replica of the network on a microchip. Within this morphologically realistic network, animal or human cells are cultured and studied under physiologically realistic flow and shear conditions. For advanced studies, tumor or tissue cells can be co-cultured within and around the microvasculature network.

The platform comprises a disposable chip that is imprinted with microvascular networks, a pump to perfuse cells, reagents, and solutions, and customized software for analysis of experimental data.

Animal or Human Scan

Digitized Version of Scan

CAD Model of Network

SynVivo Microfabrication

SynVivo Microchip

SynVivo Assay Chip

Validation of SynVivo Assay

The following is an example of comparison of SynVivo results with in vivo results for WBCs binding on inflamed endothelial cells. These results show the predictive ability of the SynVivo platform for in vivo cellular behavior.

WBCs binding on inflamed endothelial cells (SynVivo)

WBCs binding on inflamed endothelial cells (in vivo)

Cells SynVivo

Cells in vivo

Adhesion patterns in SynVivo agree very well with in vivo observations.

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